At Core Self, we offer Spravato® (esketamine) as an advanced treatment option for adults with treatment-resistant depression (TRD) and major depressive disorder with suicidal thoughts or actions. Approved by the FDA, Spravato® is a prescription nasal spray used in conjunction with an oral antidepressant and administered under medical supervision in our safe, supportive environment.

Who is Spravato® for?

Spravato® may be right for you if:

• You’ve tried two or more antidepressants without finding lasting relief.

• You experience ongoing, severe depression that significantly impacts your daily life.

• You’re navigating depression with suicidal thoughts or behaviors and need rapid symptom relief.

How It Works

Spravato® is a form of ketamine, known for its fast-acting effects on depression symptoms. Unlike traditional antidepressants, which can take weeks to work, Spravato® often begins to relieve symptoms within hours to days. It targets the brain's glutamate system, helping to restore connections and create new pathways that support mood regulation.

What to Expect

Your treatment journey will begin with a comprehensive assessment to determine if Spravato® is appropriate for you. If eligible:

• You'll visit our clinic 1–2 times per week for the first several weeks.

• Each session involves self-administering the nasal spray under the supervision of a trained provider.

• You’ll remain in our care for at least two hours after each dose for monitoring and support.

• We’ll work closely with you to track your progress and adjust your care plan as needed.

A Safe, Compassionate Setting

Core Self is committed to creating a safe, trauma-informed space for healing. Our providers are trained in both psychiatric and therapeutic care, and we understand that true healing is more than symptom management—it’s about reconnecting with your core self.